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Case Studies

Development of a Single HPLC-MS method for Lipid Soluble Vitamins, Analytical Case Studies

For a company working in the food industry, IPOS developed quantitative analysis of lipid soluble vitamins using LC-QQQ-MS in food and healthcare products. This challenging analysis used saponification of the sample and extraction of the vitamins into hexane. A normal phase method was developed that was capable of resolving cis- and trans-vitamins A, vitamin D2 and D3, and nine different components of vitamin E, some of which were isobaric. The method gave excellent linearity and was capable of quantifying many of the vitamins as low as 20 pg on-column concentration.

Development of a Single HPLC-MS method for Lipid Soluble Vitamins Analytical Case Studies

Optimisation of an Enzymatic Esterfication, Process Development Case Studies

Our client had developed an enzymatic esterification process for the production of a proprietary nutraceutical product. Their existing process resulted in numerous impurities and the key process parameters were not well understood. IPOS carried out a mechanistic investigation to identify the impurity forming reactions and applied this improved understanding towards the development of a more efficient system with significantly lower impurity levels.

Optimisation of an Enzymatic Esterfication Process Development Case Studies

Identification and Quantitation of Pesticides in Drinking Water, Analytical Case Studies

Working for a company in the environmental industry IPOS developed methods for low level detection of pesticide and herbicides using both targeted LC-QQQ-MS analysis and also HRAM screening analysis. Our extensive mass spectral pesticide/herbicide library allows thousands of compounds to be screened. One notable example from this project was the LC-QQQ-MS method for metaldehyde in drinking water. This analysis used d16-metaldehyde as an internal standard and was optimised to be capable of quantitative detection down to 1.25ppt, with a detection limit of 0.38ppt in both raw and drinking water.

Identification and Quantitation of Pesticides in Drinking Water Analytical Case Studies

Mechanistic Understanding of a Catalytic Oxidation Process in a Fuel Cell, Process Development Case Studies

Our client had developed a novel fuel cell design that used a liquid catholyte. The output of the fuel cell was dependant on the efficiency of the reoxidation of the catalyst with air. IPOS carried out a mechanistic study to understand the kinetics of the reoxidation process in the gas/liquid biphasic system. This improved process understanding was used by the company to redesign their catholyte reoxidiser and improve the output performance of the fuel cell.

Mechanistic Understanding of a Catalytic Oxidation Process in a Fuel Cell Process Development Case Studies